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Index > Protein center > PEX16(Gene name) > Human
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  • PEX16 (Gene name),
  • Peroxisomal membrane protein PEX16 (Protein name ),  PEX16_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PEX16;
    Protein name:
    Peroxisomal membrane protein PEX16;
    Alternative:
    Peroxisomal biogenesis factor 16;Peroxin-16;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PEX19.
    Function:
    Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3.
    Subcellular Location:
    Peroxisome membrane Multi-pass membrane protein Endoplasmic reticulum membrane
    Protein Attributes:
    Sequence length:
    336
    Sequence:
    50:
    MEKLRLLGLR | YQEYVTRHPA | ATAQLETAVR | GFSYLLAGRF | ADSHELSELV | 
    100:
    YSASNLLVLL | NDGILRKELR | KKLPVSLSQQ | KLLTWLSVLE | CVEVFMEMGA | 
    150:
    AKVWGEVGRW | LVIALVQLAK | AVLRMLLLLW | FKAGLQTSPP | IVPLDRETQA | 
    200:
    QPPDGDHSPG | NHEQSYVGKR | SNRVVRTLQN | TPSLHSRHWG | APQQREGRQQ | 
    250:
    QHHEELSATP | TPLGLQETIA | EFLYIARPLL | HLLSLGLWGQ | RSWKPWLLAG | 
    300:
    VVDVTSLSLL | SDRKGLTRRE | RRELRRRTIL | LLYYLLRSPF | YDRFSEARIL | 
    336:
    FLLQLLADHV | PGVGLVTRPL | MDYLPTWQKI | YFYSWG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    MIM:
    String:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Peroxisomal membrane protein PEX16
    Cat.:
    E11248h
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    96T
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    ELISA Kit for Human Peroxisomal membrane protein PEX16
    Cat.:
    E11248m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Peroxisomal membrane protein PEX16
    Cat.:
    E11248b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Peroxisomal membrane protein PEX16
    Cat.:
    U11248m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Peroxisomal membrane protein PEX16
    Cat.:
    U11248b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Peroxisomal membrane protein PEX16
    Cat.:
    U11248h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Peroxisomal membrane protein PEX16
    Cat.:
    P11248Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Peroxisomal membrane protein PEX16
    Polyclonal Antibody for Human Peroxisomal membrane protein PEX16
    Cat.:
    P11248Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Peroxisomal membrane protein PEX16
    Monoclonal Antibody for Human Peroxisomal membrane protein PEX16
    Monoclonal Antibody for Human Peroxisomal membrane protein PEX16
    Protein for Human Peroxisomal membrane protein PEX16
    Protein for Human Peroxisomal membrane protein PEX16
    Protein for Human Peroxisomal membrane protein PEX16

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    Linearity
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    References
    1. 1.
      "Mutation in PEX16 is causal in the peroxisome-deficient Zellweger syndrome of complementation group D."
      Honsho M. , Tamura S. , Shimozawa N. , Suzuki Y. , Kondo N. , Fujiki Y.
      Am. J. Hum. Genet.63:1622-1630(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INVOLVEMENT IN PBD-CG9 AND PBD8A;VARIANT ILE-116
    2. 2.
      "Peroxisome synthesis in the absence of preexisting peroxisomes."
      South S.T. , Gould S.J.
      J. Cell Biol.144:255-266(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ILE-116
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ILE-116
      tissue: Lung.
    5. 5.
      "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis."
      Sacksteder K.A. , Jones J.M. , South S.T. , Li X. , Liu Y. , Gould S.J.
      J. Cell Biol.148:931-944(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PEX19
    6. 6.
      "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences."
      Fransen M. , Wylin T. , Brees C. , Mannaerts G.P. , Van Veldhoven P.P.
      Mol. Cell. Biol.21:4413-4424(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PEX19;SUBCELLULAR LOCATION
    7. 7.
      "The membrane biogenesis peroxin Pex16p. Topogenesis and functional roles in peroxisomal membrane assembly."
      Honsho M. , Hiroshige T. , Fujiki Y.
      J. Biol. Chem.277:44513-44524(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TOPOLOGY
    8. 8.
      "PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins."
      Jones J.M. , Morrell J.C. , Gould S.J.
      J. Cell Biol.164:57-67(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PEX19
    9. 9.
      "The origin and maintenance of mammalian peroxisomes involves a de novo PEX16-dependent pathway from the ER."
      Kim P.K. , Mullen R.T. , Schumann U. , Lippincott-Schwartz J.
      J. Cell Biol.173:521-532(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "Identification of an unusual variant peroxisome biogenesis disorder caused by mutations in the PEX16 gene."
      Ebberink M.S. , Csanyi B. , Chong W.K. , Denis S. , Sharp P. , Mooijer P.A. , Dekker C.J. , Spooner C. , Ngu L.H. , De Sousa C. , Wanders R.J. , Fietz M.J. , Clayton P.T. , Waterham H.R. , Ferdinandusse S.
      J. Med. Genet.47:608-615(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PBD8B VAL-252 DEL; THR-289 AND CYS-331
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